Uji Mutagenik Ames Untuk Melengkapi Data Keamanan Ekstrak Gambir (Uncaria Gambir Roxb.)

The main compound of Uncaria gambir Roxb. (gambir), catechin and it\u27s derivates have been believed to be potential as antiviral. Epigallocatechin gallate (EGCG) and epicatechin are catechin derivates which are found to be potential as antiviral against Human Immunodeficiency Virus (HIV). However, gambir extract also contains quercetin that has possibility to be mutagenic. Therefore, a preliminary study towards safety of those compounds within gambir extract, mutagenicity assay using Ames Method has been performed.Sample (gambir extract) was obtained from West Sumatera, Indonesia. The extract was characterized according to Farmakope Herbal Indonesia and WHO methods. Mutagenicity test by Ames method utilized a colorimetric microplate in 6 various concentration (125 mg/mL; 62.5 mg/mL; 31.25 mg/mL; 15.625 mg/mL; 7.81 mg/mL dan 3.91 mg/mL) against mutant bacteria Salmonella typhimurium TA 98, Salmonella typhimurium TA 100 and Escherichia coli WP2 uvrA with and without the addition of S-9 enzyme. Extract of gambir in this study contains 86.60% of catechin, 12.92% moisture content, 22.49% water-soluble extract content, 80.63% ethanol-soluble extract content, 0.81% total ash, 0.32% acid insoluble ash content and 10.38% in dryness level. From the mutagenicity test and calculation, fold increase (over baseline) of the sample in 6 various concentration with and without adding S-9 enzyme are lower than 2. Gambir extract from West Sumatra with catechin contains 86.6% hasn\u27t showed mutagenic effect due to the fold increase (over baseline) of mutagenicity test lower than 2

The Development of Learning Module Trigonometry Equation Material Integrated Islamic Values to Improve Students Learning Outcome

Penelitian ini bertujuan untuk menghasilkan modul matematika yang terintegrasi dengan nilai-nilai Islam dengan penilaian otentik untuk siswa kelas sebelas MA Hasyim Asy'ari Bangsri, Sukodono, Sidoarjo, yang layak dan unggul untuk meningkatkan prestasi siswa dalam matematika. Penelitian ini menerapkan Model pengembangan Plomp. Metode pengumpulan data dalam penelitian ini adalah dengan menggunakan kuesioner dan tes. Data dianalisis secara kuantitatif dan divalidasi. Hasil penelitian ini adalah: 1) Modul Matematika Nilai Islam dilampirkan dengan penilaian otentik dalam proses belajar mengajar. 2) Hasil penilaian ahli terhadap bahan ajar menunjukkan bahwa pengembangan modul matematika nilai-nilai islami dengan penilaian otentik memenuhi syarat baik. 3) Validator media memberikan respons yang baik. 4) Persentase keseluruhan tanggapan siswa pada tes kelompok kecil adalah 88% yang dapat dianggap memiliki kualifikasi yang baik. 5) Tanggapan guru pada tes lapangan menunjukkan bahwa guru merespons dengan baik. 6) Pengembangan modul matematika realistis ini efektif untuk meningkatkan hasil belajar siswa kelas sebelas di MA Hasyim Asy'ari Bangsri, Sukodono, Sidoarjo. Kata kunci: pengembangan, model Plomp, modul matematika, penilaian otentik, prestasi belajar matematik

Pengaruh Persepsi, Motivasi, Pengetahuan Akuntansi, Jangka Waktu Studi Terhadap Minat Melanjutkan Studi Pada Program Pendidikan Profesi Akuntansi

The program for accounting study in Indonesia had many changes since 1960, and the most significant is in the 2001 when National Education Ministry issued decree No. 179/U/2001 about Accountancy Profession Program. This program is intended for bachelor who want get their Accountant degree, because before 2004 every bachelor had their Accountant degree automatically. This study finds that perception, knowledge of accounting, and time for study are significantly affect the interest for bachelor to continue their study at Accountancy Profession Program

Ipteks Peraturan Pemerintah No.71 Tahun 2010 Tentang Akuntansi Pemerintahan Berbasis Akrual pada Badan Penanggulangan Bencana Daerah Provinsi Sulawesi Utara

Organization of Prov. Regional Disaster Management Agency North Sulawesi Moves in the Field of Disaster Management Operations Centers which need to implement Government Regulation No. 71 of 2010 on accrual bases to provide information from financial records and facilitate more effective performance. In accounting there are two records of the first cash basis and accrual basis. Accrual Basis is the basis for facilitating performance measurement, in regulating clearer and more understandable. This study uses descriptive research methods that aim to explain the circumstances, events or everything related to programs that can be explained in words or numbers. The application of Government Regulation No. 71 of 2010 concerning accrual basis is certainly in accordance with what has been implemented by the Law that has been implemented by the government, Government Accounting Standards, Financial Accounting Standards. Accrual basis application needs financial statements, so that problems can be found or what things are not in accordance with the activities of either budgeting or calculation of budgeting

Statistical properties of acoustic emission signals from metal cutting processes

Acoustic Emission (AE) data from single point turning machining are analysed in this paper in order to gain a greater insight of the signal statistical properties for Tool Condition Monitoring (TCM) applications. A statistical analysis of the time series data amplitude and root mean square (RMS) value at various tool wear levels are performed, �nding that ageing features can be revealed in all cases from the observed experimental histograms. In particular, AE data amplitudes are shown to be distributed with a power-law behaviour above a cross-over value. An analytic model for the RMS values probability density function (pdf) is obtained resorting to the Jaynes' maximum entropy principle (MEp); novel technique of constraining the modelling function under few fractional moments, instead of a greater amount of ordinary moments, leads to well-tailored functions for experimental histograms.Comment: 16 pages, 7 figure

Modeling functional network topology following stroke through graph theory:functional reorganization and motor recovery prediction

The study of functional reorganization following stroke has been steadily growing supported by advances in neuroimaging techniques, such as functional magnetic resonance imaging (fMRI). Concomitantly, graph theory has been increasingly employed in neuroscience to model the brain's functional connectivity (FC) and to investigate it in a variety of contexts. The aims of this study were: 1) to investigate the reorganization of network topology in the ipsilesional (IL) and contralesional (CL) hemispheres of stroke patients with (motor stroke group) and without (control stroke group) motor impairment, and 2) to predict motor recovery through the relationship between local topological variations of the functional network and increased motor function. We modeled the brain's FC as a graph using fMRI data, and we characterized its interactions with the following graph metrics: degree, clustering coefficient, characteristic path length, and betweenness centrality (BC). For both patient groups, BC yielded the largest variations between the two analyzed time points, especially in the motor stroke group. This group presented significant correlations (P<0.05) between average BC changes and the improvements in upper-extremity Fugl-Meyer (UE-FM) scores at the primary sensorimotor cortex and the supplementary motor area for the CL hemisphere. These regions participate in processes related to the selection, planning, and execution of movement. Generally, higher increases in average BC over these areas were related to larger improvements in UE-FM assessment. Although the sample was small, these results suggest the possibility of using BC as an indication of brain plasticity mechanisms following stroke

ANALISIS LAPISAN PELINDUNG PADA COAL FEEDER DAN COAL MILL DI PERUSAHAAN PUPUK

Coal feeder dan coal mill dalam area UBB perusahaan pupuk merupakan alat yang digunakan untuk menyuplai bahan bakar batu bara ke boiler. Kedua alat tersebut dilengkapi dengan safeguard yang bekerja sesuai fungsi. Jika terjadi kegagalan fungsi safeguard, maka dapat terjadi peledakan dan kebakaran yang dapat membahayakan karyawan dan masyarakat sekitar perusahaan. Oleh karena itu, penelitian ini menganalisis kecukupan safeguard dan analisis SIL pada coal feeder dan coal mill. Penelitian ini menggunakan metode Failure Mode and Effect Analysis (FMEA) untuk mengidentifikasi potensi bahaya dan tingkat risiko pada komponen coal feeder dan coal mill. Selanjutnya hasil dari FMEA dilakukan analisis kecukupan pelindung menggunakan metode Layer Of Protection Analysis (LOPA) dan menentukan nilai SIL (Safety Integrity Level). Berdasarkan hasil identifikasi bahaya menggunakan metode FMEA terdapat tiga consequence dengan tingkat risiko tertinggi yaitu coal feeder memiliki 1 consequence dan coal mill memiliki 2 consequence. Berdasarkan hasil penelitian untuk frekuensi skenario kesatu, kedua dan ketiga didapatkan 1,26×10-2 , 9,8×10-3 dan 1,50×10-2 per tahun. Didapatkan hasil bahwa risiko berada pada tingkat tidak dapat diterima. Rekomendasi yang dapat diterapkan adalah penambahan IPL yang dapat mereduksi frekuensi skenario hingga dapat diterima. Dari PFD yang ditentukan dapat diketahui untuk skenario kesatu adalah SIL 3, skenario kedua SIL 2 dan Skenario ketiga adalah SIL 3. Kata Kunci: Coal Feeder, Coal Mill, FMEA, LOPA, SI

Association between hemodynamic activity and motor performance in six-month-old full-term and preterm infants: a functional near-infrared spectroscopy study

FAPEMIG - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE MINAS GERAISFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOThis study aimed to assess task-induced activation in motor cortex and its association with motor performance in full-term and preterm born infants at six months old. A cross-sectional study of 73 sixmonth- old infants was conducted (35 full-term and 38 preterm infants). Motor performance was assessed using the Bayley Scales of Infant Development third edition-Bayley-III. Brain hemodynamic activity during motor task was measured by functional near-infrared spectroscopy (fNIRS). Motor performance was similar in full-term and preterm infants. However, differences in hemodynamic response were identified. Full terms showed a more homogeneous unilateral and contralateral activated area, whereas in preterm-born the activation response was predominantly bilateral. The full-term group also exhibited a shorter latency for the hemodynamic response than the preterm group. Hemodynamic activity in the left sensorimotor region was positively associated with motor performance measured by Bayley-III. The results highlight the adequacy of fNIRS to assess differences in task-induced activation in sensorimotor cortex between groups. The association between motor performance and the hemodynamic activity require further investigation and suggest that fNIRS can become a suitable auxiliary tool to investigate aspects of neural basis on early development of motor abilities.5118FAPEMIG - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE MINAS GERAISFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOFAPEMIG - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE MINAS GERAISFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO215502012/02500-82013/07559-